| Date & Time | Division | Game | Venue |
|---|---|---|---|
| November 13, 2021 | (3) UNH at (6) Northeastern | Mullins Center | |
| November 13, 2021 | (6) Plymouth State at (3) UMass-Dartmouth
NCAA Division III |
Falmouth Ice Arena | |
| November 13, 2021 | (6) FGCU at (2) UMass | Mullins Center | |
| November 12, 2021 | (3) FGCU at (5) Northeastern | Mullins Center | |
| November 12, 2021 | (3) UNH at (4) UMass | Mullins Center |
