| Date & Time | Game | Venue |
|---|---|---|
| December 09, 2021 | (3) Medway/Ashland Mustangs at (2) Newton North/South Tigers | John A. Ryan Arena |
| December 11, 2021 | (1) HPNA Hillies at (1) Newton North/South Tigers
1-1 (OT) |
John A. Ryan Arena |
| December 14, 2021 | (0) Newton North/South Tigers at (1) Wayland/Weston Warcats | MacDowell Ice Arena |
| December 15, 2021 | (0) Newton North/South Tigers at (2) Wellesley/Lincoln-Sudbury Raiders | Wellesley Sports Center |
| Dec. 18 Postponed | Newton North/South Tigers at Framingham Flyers
make-up TBA |
Loring Arena |
| December 21, 2021 | (0) Newton North/South Tigers at (2) Auburn Rockets | Horgan Skating Arena |
| January 05, 2022 | (2) Brookline Warriors at (0) Newton North/South Tigers | John A. Ryan Arena |
| Jan. 8 (Time TBA) | (2) Newton North/South Tigers at (3) Natick Red Hawks | Chase Arena |
| January 12, 2022 | (0) Newton North/South Tigers at (2) Needham Rockets | Babson Skating Center |
| Jan. 15 Postponed | Waltham Hawks at Newton North/South Tigers
make-up TBA |
John A. Ryan Arena |
| January 19, 2022 | (0) Westford Academy Ghosts at (1) Newton North/South Tigers | John A. Ryan Arena |
| January 22, 2022 | (0) Newton North/South Tigers at (4) Weymouth Wildcats | Connell Memorial Rink |
| January 24, 2022 | (0) Waltham Hawks at (3) Newton North/South Tigers | Reilly Memorial Rink |
| January 26, 2022 | (7) Braintree Wamps at (0) Newton North/South Tigers | John A. Ryan Arena |
| Jan. 28 Postponed | Newton North/South Tigers at Walpole Timberwolves
PPD from 1-28 |
Rodman Arena |
| January 31, 2022 | (4) Newton North/South Tigers at (1) Concord-Carlisle Patriots | Edge Sports Center |
| February 01, 2022 | (1) Wellesley/Lincoln-Sudbury Raiders at (2) Newton North/South Tigers | John A. Ryan Arena |
| February 05, 2022 | (1) Newton North/South Tigers at (1) Brookline Warriors | Walter Brown Arena |
| February 07, 2022 | (0) Newton North/South Tigers at (0) Framingham Flyers | Loring Arena |
| February 09, 2022 | (4) Natick Red Hawks at (2) Newton North/South Tigers | John A. Ryan Arena |
| February 12, 2022 | (1) Milton Wildcats at (0) Newton North/South Tigers | John A. Ryan Arena |
| February 14, 2022 | (0) Newton North/South Tigers at (1) Walpole Timberwolves | Rodman Arena |
| February 16, 2022 | (1) Framingham Flyers at (0) Newton North/South Tigers | John A. Ryan Arena |
