| Date & Time | Game | Venue |
|---|---|---|
| December 16, 2021 | (10) Algonquin/Hudson Titans at (0) Franklin Panthers | Pirelli Veterans Arena |
| December 21, 2021 | (2) King Philip Warriors at (3) Franklin Panthers | Pirelli Veterans Arena |
| December 29, 2021 | (2) Franklin Panthers at (1) Dedham Marauders | Noble & Greenough School |
| December 31, 2021 | (2) Longmeadow Lancers at (2) Franklin Panthers | Pirelli Veterans Arena |
| January 04, 2022 | (0) Franklin Panthers at (3) Canton Bulldogs | Metropolis Ice Rink |
| January 08, 2022 | (1) Dedham Marauders at (2) Franklin Panthers | Pirelli Veterans Arena |
| January 12, 2022 | (0) Franklin Panthers at (5) Westwood Wolverines | Canton Ice House |
| January 15, 2022 | (3) Franklin Panthers at (3) Medway/Ashland Mustangs | New England Sports Center |
| January 17, 2022 | (1) Franklin Panthers at (1) Algonquin/Hudson Titans | New England Sports Center |
| January 19, 2022 | (0) Franklin Panthers at (1) Medfield Warriors | Boch Ice Center |
| January 22, 2022 | (4) Norwood Mustangs at (1) Franklin Panthers | Pirelli Veterans Arena |
| January 26, 2022 | (4) Franklin Panthers at (6) King Philip Warriors | Foxboro Sports Center |
| Jan. 29 Postponed | Canton Bulldogs at Franklin Panthers
PPD from 1-29 |
Pirelli Veterans Arena |
| February 03, 2022 | (2) MOA Warriors at (5) Franklin Panthers | Pirelli Veterans Arena |
| February 06, 2022 | (2) Franklin Panthers at (2) East/West Bridgewater Vikings | Bridgewater Ice Arena |
| February 09, 2022 | (2) Franklin Panthers at (4) Longmeadow Lancers | Cyr Arena |
| February 13, 2022 | (3) Franklin Panthers at (2) MOA Warriors | Foxboro Sports Center |
| February 14, 2022 | (4) Franklin Panthers at (7) Norwood Mustangs | The Skating Club of Boston |
| February 22, 2022 | (2) Canton Bulldogs at (1) Franklin Panthers | Pirelli Veterans Arena |
| February 23, 2022 | (1) Franklin Panthers at (2) Wellesley/Lincoln-Sudbury Raiders | Wellesley Sports Center |
| March 04, 2022 | (0) Franklin Panthers at (4) Andover Golden Warriors
Girls Division 2 Tournament |
Breakaway Ice Center |
