| Date & Time | Game | Venue |
|---|---|---|
| December 09, 2021 | (0) Medford/Malden Mustangs at (3) Marblehead Magicians | Rockett Arena |
| December 15, 2021 | (0) Masconomet Chieftains at (2) Medford/Malden Mustangs | LoConte Rink |
| December 18, 2021 | (2) Medford/Malden Mustangs at (1) Gloucester Fishermen | Dorothy Talbot Rink |
| December 22, 2021 | (6) Beverly/Danvers/Ipswich Panthers at (2) Medford/Malden Mustangs | LoConte Rink |
| Jan. 5 Postponed | Medford/Malden Mustangs at Winthrop Vikings | Larsen Rink |
| Jan. 8 Postponed | Shawsheen/Bedford/Lowell Rams at Medford/Malden Mustangs | LoConte Rink |
| January 12, 2022 | (8) Bishop Fenwick Crusaders at (2) Medford/Malden Mustangs | LoConte Rink |
| January 15, 2022 | (1) Medford/Malden Mustangs at (3) Melrose Red Hawks | Flynn Memorial Rink |
| January 17, 2022 | (1) Medford/Malden Mustangs at (8) Peabody/Lynnfield/North Reading Tanners | McVann-O'Keefe Skating Rink |
| January 19, 2022 | (0) Medford/Malden Mustangs at (5) Watertown Raiders | John A. Ryan Arena |
| January 22, 2022 | (6) Newburyport Clippers at (3) Medford/Malden Mustangs | LoConte Rink |
| January 26, 2022 | (4) Marblehead Magicians at (2) Medford/Malden Mustangs | LoConte Rink |
| February 02, 2022 | (2) Medford/Malden Mustangs at (3) Masconomet Chieftains | Haverhill Valley Forum |
| February 05, 2022 | (2) Gloucester Fishermen at (1) Medford/Malden Mustangs | LoConte Rink |
| February 09, 2022 | (0) Medford/Malden Mustangs at (3) Beverly/Danvers/Ipswich Panthers | Raymond J. Bourque Arena |
| February 12, 2022 | (1) Melrose Red Hawks at (3) Medford/Malden Mustangs | LoConte Rink |
| February 14, 2022 | (10) Winthrop Vikings at (1) Medford/Malden Mustangs | LoConte Rink |
| February 16, 2022 | (3) Medford/Malden Mustangs at (0) Shawsheen/Bedford/Lowell Rams | Janas Memorial Rink |
| February 19, 2022 | (6) Peabody/Lynnfield/North Reading Tanners at (1) Medford/Malden Mustangs | LoConte Rink |
| February 22, 2022 | (1) Medford/Malden Mustangs at (6) Newburyport Clippers
NEWBURYPORT BANK CLASSIC |
Graf Rink |
