| Date & Time | Game | Venue |
|---|---|---|
| January 02, 2021 | (3) Plymouth South Panthers at (4) Whitman-Hanson Panthers | Rockland Arena |
| January 06, 2021 | (8) Hanover Hawks at (0) Plymouth South Panthers
time updated |
Armstrong Arena |
| January 09, 2021 | (2) Plymouth South Panthers at (3) Pembroke Titans | Hobomock Arena |
| January 16, 2021 | (2) Plymouth South Panthers at (6) Duxbury Dragons | The Bog |
| January 18, 2021 | (2) Plymouth South Panthers at (4) North Quincy Red Raiders | Quincy Youth Arena |
| Jan. 20 Postponed | Scituate Sailors at Plymouth South Panthers | Armstrong Arena |
| January 22, 2021 | (2) Plymouth South Panthers at (6) Scituate Sailors | Hobomock Arena |
| January 27, 2021 | (3) Pembroke Titans at (3) Plymouth South Panthers | Armstrong Arena |
| January 29, 2021 | (1) Quincy Presidents at (7) Plymouth South Panthers | Armstrong Arena |
| January 30, 2021 | (4) Plymouth South Panthers at (12) Quincy Presidents | Quincy Youth Arena |
| February 03, 2021 | (3) North Quincy Red Raiders at (3) Plymouth South Panthers | Armstrong Arena |
| February 06, 2021 | (4) Plymouth South Panthers at (8) Scituate Sailors
Time updated |
Gallo Arena |
| February 10, 2021 | (5) Duxbury Dragons at (1) Plymouth South Panthers
PATRIOT CUP ( 1st Round ) |
Armstrong Arena |
